With so many choices on the market for nitric oxide supplements, how do you know which is most effective? Most manufacturers choose to use arginine, beetroot, and spinach despite existing research that shows that arginine is not efficient or effective for people over 40. Even more recently, research shows that beets and spinach are HIGH in oxalates which encourage kidney stones. Instead, we chose the highest N-O-containing food as well as the lowest oxalate contributor: arugula. We also utilized L-5-MTHF (methyltetrahydrofolate) for those genetically having trouble converting dietary nitrate. By boosting nitric oxide levels, it helps improve blood circulation, optimize oxygen delivery to muscles, and increase endurance during physical activities. This natural formula supports healthy blood pressure, promotes vascular health, and aids in faster recovery after workouts.

The Health Benefits of the Ingredients in Nitric Oxide Booster

1. Vitamin C-  Vitamin C helps stabilize and regenerate tetrahydrobiopterin (BH4), a critical cofactor for endothelial nitric oxide synthase (eNOS)—the enzyme that produces nitric oxide.

2. Thiamin- Thiamin helps maintain the health of endothelial cells, which produce nitric oxide via the enzyme endothelial nitric oxide synthase (eNOS).
Deficiency in thiamin can impair endothelial function, leading to reduced NO availability and vascular stiffness.

3. Folate- Folate supports the regeneration of BH₄, a vital cofactor for endothelial nitric oxide synthase (eNOS), the enzyme responsible for producing nitric oxide.

4. Vitamin B12- Vitamin B12 works synergistically with folate and vitamin B6 to convert homocysteine (a potentially toxic amino acid) into methionine.
Elevated homocysteine levels can damage endothelial cells and reduce nitric oxide availability by promoting oxidative stress. Adequate B12 helps lower homocysteine, preserving healthy NO signaling and vascular tone.

5. Magnesium-  Magnesium deficiency is linked to endothelial dysfunction, a condition where the endothelium loses its ability to produce nitric oxide effectively. Restoring magnesium levels improves vascular tone, elasticity, and NO-mediated blood vessel dilation.

6. Zinc-  Zinc is an essential structural component of endothelial nitric oxide synthase (eNOS), the enzyme responsible for producing nitric oxide in blood vessels. Adequate zinc helps stabilize the eNOS enzyme and supports its ability to generate NO efficiently. Low zinc levels can lead to “uncoupling” of eNOS, resulting in oxidative stress and reduced NO output.

7. Copper- Copper acts as a cofactor for enzymes that regulate endothelial nitric oxide synthase (eNOS), the enzyme responsible for producing nitric oxide in blood vessel walls. Adequate copper levels help maintain eNOS structure and activity, supporting steady nitric oxide synthesis and vascular tone.

8. Potassium- Potassium intake is associated with lower oxidative stress and vascular inflammation, both of which degrade nitric oxide and impair its signaling. By lowering inflammation, potassium helps preserve NO bioavailability in the vascular system.

Proprietary Blend of the Following which work synergistically to support healthy circulation. 

  - Amino Acids (L-Arginine & L-Citruline):  L-Arginine is the immediate raw material your body uses to make nitric oxide via the nitric oxide synthase (NOS) enzyme pathway. L-Citrulline is converted into L-Arginine inside your kidneys, which then raises N.O. levels more effectively than taking arginine alone.
It’s also gentler on digestion and stays active longer. Enhances endurance, circulation, and muscle recovery. Citrulline raises and sustains arginine levels in the blood. Arginine provides an immediate N.O. boost. The combo can enhance vasodilation, energy, and performance more than either alone.

  -Calcium Phosphate:  Inside your blood vessels, nitric oxide (NO) is made by an enzyme called endothelial nitric oxide synthase (eNOS).
To activate eNOS and make nitric oxide, your cells need calcium ions (Ca²⁺). Adequate calcium availability inside cells = proper N.O. production and vascular relaxation. Too little or too much calcium (especially outside the cell) can disrupt that balance.

  - Hawthorne Berry Extract:  Hawthorn’s active compounds — flavonoids,activate endothelial nitric oxide synthase (eNOS). eNOS is the enzyme that converts L-arginine → nitric oxide (NO) inside blood vessel walls.

  - Epimedium Sagitatum Extract: Epimedium sagittatum (also known as Horny Goat Weed) has well-documented effects on nitric oxide (N.O.) levels, blood flow, and sexual and cardiovascular function. Icariin stimulates endothelial nitric oxide synthase (eNOS) — the enzyme that converts L-arginine → nitric oxide inside blood vessel linings.

  - Arugula leaf extract:  Nitric oxide from arugula enhances muscle oxygen efficiency — your body uses less oxygen for the same workload. This means: Better endurance, Faster recovery, Reduced fatigue during exercise. 

  - Chrysin (5,7-Dihydroxyflavon): Chrysin (5,7-Dihydroxyflavone) is a naturally occurring flavonoid found in passionflower (Passiflora caerulea), honey, bee propolis, and some mushrooms. Most people know chrysin for its anti-inflammatory and hormone-modulating properties, but it also has important vascular and nitric oxide (N.O.)–related effects that support healthy endothelial function, circulation, and oxidative balance.

----Suitable for vegetarians and vegans. Made in a facility that processes milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soy). Gluten and gelatin-free.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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